Dihydrocoumarin ine chepfu here?

Dihydrocoumarin, kunhuhwirira, kunoshandiswa mukudya, kunoshandiswawo sechinotsiva coumarin, kunoshandiswa sekuravira kwekunaka; Kirimu yakasanganiswa, kokonati, kuravira kwesinamoni; Inoshandiswawo sekuravira kwefodya.

Dihydrocoumarin ine chepfu here?

Dihydrocoumarin haina chepfu. Dihydrocoumarin chigadzirwa chechisikigo chinowanikwa muyero vanilla rhinoceros. Inogadzirwa nehydrogenation ye coumarin paine nickel catalyst pa 160-200 ℃ uye iri pasi pekumanikidzwa. Inogona zvakare kushandiswa sezvinhu zvisina kubikwa, hydrolyzed mu alkaline aqueous solution kugadzira o-hydroxyphenylpropionic acid, dehydration, closed-loop inowanikwa.

Mamiriro ekuchengetedza

Yakavharwa uye yakasviba, yakachengetwa munzvimbo inotonhorera uye yakaoma, nzvimbo iri mubhari diki sezvinobvira pasi pemvumo dzekuchengetedza, uye yakazadzwa nekuchengetedzwa kwenitrogen. Chengeta mudura rinotonhorera, rine mhepo inofefetera. Gara kure nemoto, mvura. Inofanira kuchengetwa yakasiyana neoxidizer, usasanganisa nzvimbo yekuchengetera. Yakashongedzerwa nemhando dzakasiyana-siyana uye huwandu hwemidziyo yemoto inoenderana.

Chidzidzo che in vitro

Kuyedzwa kwe enzymatic mu vitro, dihydrocoumarin yakakonzera kudzikiswa kweSIRT1 (IC50 ye208μM) zvichienderana nehuwandu hwemasero. Kudzikira kwekushanda kweSIRT1 deacetylase kwakaonekwa kunyangwe pa micromolar doses (85±5.8 uye 73± 13.7% activity pa1.6μM uye 8μM, zvichiteerana). Microtubule SIRT2 deacetylase yakadziviswawo nenzira yakafanana inoenderana nehuwandu (IC50 ye295μM).

Mushure memaawa makumi maviri nemana ekushandiswa mushonga uyu, dihydrocoumarin (1-5mM) yakawedzera hutachiona mumasero eTK6 nenzira inoenderana nedosi. Dihydrocoumarin (1-5mM) yakawedzera apoptosis mumasero eTK6 nenzira inoenderana nedosi panguva yemaawa matanhatu. Dosi ye5mM ye dihydrocoumarin yakawedzera apoptosis panguva yemaawa matanhatu mumasero eTK6. Mushure menguva yemaawa makumi maviri nemana, dihydrocoumarin (1-5mM) yakawedzera p53 lysine 373 uye 382 acetylation nenzira inoenderana nedosi mumasero eTK6.