ISIHYDROCOOCUMARIN ICOTEC

Dihydrocoucin, kunhuhwirira, anoshandiswa mune chikafu, anoshandiswawo semakosi ekutsiva, anoshandiswa se cosmetic flavor; Sanganisa kirimu, koni, cinnamon flavor; Izvo zvinoshandiswawo sefakara fodya.

ISIHYDROCOOCUMARIN ICOTEC

Dihydrococoumarin haina chepfu. Dihydrococococoucin chigadzirwa chechisikigo chakawanikwa mune yellow vanilla Rhinoceros. Iyo yakagadzirirwa ne hydrogenation yemakonzo pamberi peiyo nickel inochera na 160-200 ℃ uye pasi pekumanikidzwa. Inogona zvakare kushandiswa seyakaisa zvinhu, hydrolyzed muAlkaline yemvura mhinduro yekugadzira o-hydroxyphenylpropionclpropionclpropionclpropioncalpionic acid, kushomeka, yakavharwa-loop yakawanikwa.

Kuchengetedza mamiriro

Yakavharwa uye yakasviba, yakachengetwa munzvimbo inotonhorera uye yakaoma, iyo nzvimbo iri mubhari ishoma sezvinobvira pasi pemvumo yekuchengetedza, uye izere ne nitrogen kuchengetedzwa. Chengetedza muchitoro chinotonhorera, chakavanzika. Gara kure nemoto, mvura. Inofanira kuchengetwa zvakasiyana kubva kune oxidizer, usasanganisa kuchengetedza. Yakarongedzwa nemhando dzakasiyana-siyana uye huwandu hwemidziyo yemoto.

Mu vitro kudzidza

Mu vitro enzymatic assay, Dihydrocoucin yakakurudzira kudzvanywa-inotsamira inhibition ye sirt1 (Ic50 of 208μm). Kuderedza mu Sirt1 Deacetylase Basa rakacherechedzwa kunyange kuMicromolar Doses (85 ± 5.8 uye 73】 13.7% chiitiko pa1.6μm uye 8μm, zvichiteerana). MicroTubule sirt2 Deacetylase yakadzvanywawo mune yakafanana dosi-inoenderana nemaitiro (IC50 ye 295μm).

Mushure memaawa makumi maviri nemana ekuratidzwa, dehydrocoucin (1-5mm) yakawedzera cytototicity mune tk6 cell mitsara mune dosi-inoenderana nemaitiro. Dihydrocoucumarin (1-5mm) yakawedzera apoptosis in tk6 cell mitsara mune dosi-inochengetedza nzira panguva yemaawa matanhatu-nguva nguva. Iyo 5mm dosi yeDhiyydrocoucin yakawedzera apoptosis panguva ye6-awa nguva inzira yeTK6 cell mutsara. Mushure mekubuda kwemaawa makumi maviri nemana, Dihydrocoumarin (1-5mm) yakawedzera p53 Lysine 373 uye 382 Acetylation muThe-DELSETION NOTK LINE.