Triclosanis a wide spectrum antimicrobial inoshandiswa seantiseptic, disinfectant kana preservative muzvipatara, zvigadzirwa zvakasiyana-siyana zvevatengi zvinosanganisira zvizorwa, zvigadzirwa zvekuchenesa mudzimba, zvigadzirwa zvepurasitiki, matoyi, pendi, etc. Inosanganiswawo pamusoro pezvigadzirwa zvekurapa, zvinhu zvepurasitiki, machira, midziyo yemukicheni, nezvimwewo, kubva iyo inogona kudonha zvishoma nezvishoma kwenguva yakareba panguva yekushandiswa kwavo, kuita biocidal action.
Ko triclosan inoshandiswa sei muzvizoro?
Triclosanyakanyorwa muna 1986 muEuropean Community Cosmetics Directive kuti ishandiswe sekuchengetedza muzvigadzirwa zvecosmetic pamitsetse inosvika 0.3%.Ongororo yengozi ichangoburwa yakaitwa neEU Scientific Committee yeConsumer Products yakagumisa kuti, kunyangwe kushandiswa kwayo kwakawanda kwe 0.3% mumishonga yemazino, sipo dzemaoko, sipo dzemuviri / gels dzekugezesa uye zvimiti zvinonhuwirira zvakaonekwa zvakachengeteka pane toxicological point yekuona. Zvigadzirwa zvega, ukuru hwekuratidzwa kweaggregate kune triclosan kubva kune zvese zvigadzirwa zvekuzora hazvina kuchengeteka.
Chero kumwezve kushandiswa kwetriclosan muhupfu hwechiso uye kuvanza kwakasvibiswa panzvimbo iyi kwainziwo kwakachengeteka, asi kushandiswa kwetriclosan mune zvimwe zvigadzirwa zvekusiya-pane (semuenzaniso mafuta ekuzora) uye mukugezesa muromo hakuna kunzi kwakachengeteka kune mutengi nekuda kwekukwira kwakakwira. exposures.Kufemerwa netriclosan kubva muzvigadzirwa zvekupfapfaidza (eg madhiraidhi) hazvina kuongororwa.
Triclosankunge isiri-ionic, inogona kugadzirwa mune yakajairika dentifrices.Zvisinei, haisungiri kumuromo wemuromo kweanopfuura maawa mashomanana, uye naizvozvo haibudisi nhanho yakadzikama ye anti-plaque basa.Kuwedzera kutora uye kuchengetwa kwetriclosan nemuromo pamusoro pekuvandudzwa kwekugadzirisa kweplaque uye hutano hwegingival, triclosan / polyvinylmethyl ether maleic acid copolymer uye triclosan / zinc citrate uye triclosan / calcium carbonate dentifrice inoshandiswa.
Ko triclosan inoshandiswa sei muhutano hwehutano uye michina yekurapa?
Triclosanyakashandiswa zvinobudirira mukurapa kubvisa tupukanana tudiki senge methicillin-resistant Staphylococcus aureus (MRSA) , kunyanya nekurudziro yekushandisa 2% triclosan bath.Triclosan inoshandiswa pakuvhiya, uye inoshandiswa zvakanyanya mukugeza maoko uye sekugeza muviri kubvisa MRSA kubva kune vatakuri vasati vavhiyiwa.
Triclosan inoshandiswa mumichina yekurapa yakati wandei, semuenzaniso ureteral stents, sutures yekuvhiya uye inogona kutariswa kudzivirira hutachiona.Bojar et al havana kuona mutsauko wekoloni pakati petriclosan-coated sutures uye nguva dzose multifilament suture, kunyange zvazvo basa ravo raisanganisira mabhakitiriya mashanu uye rinongobva pakugadzirisa nzvimbo yekudzivisa.
Mune ureteral stents, triclosan yakaratidzwa kuti inodzivisa kukura kweakajairika mabhakitiriya uropathogens uye kuderedza chiitiko cheurinary-tract infections uye, zvichida, catheter encrustation ichangobva kuratidza synergistic migumisiro ye triclosan uye maantibioti akakodzera pamakiriniki akazvitsaura anosanganisira manomwe uropathogenic marudzi, uye vanotsigira kushandiswa kwetriclosan-eluting stent kana zvichidikanwa, pamwe chete nemishonga inorwisa mabhakitiriya mukurapa varwere vakaoma.
Mune zvimwe zviitiko, kushandiswa kwetriclosan mune weti Foley catheter kwakakurudzirwa sezvo triclosan yakabudirira kuvharira kukura kweProteus mirabilis uye kudzora kuvharirwa uye kuvharika kwecatheter.Munguva pfupi yapfuura, Daruiche et al.yakaratidza synergistic, wide-spectrum uye yakasimba antimicrobial activity ye catheter yakavharwa nemusanganiswa wetriclosan uye DispersinB, an anti-biofilm enzyme inodzivisa uye inoparadzira biofilms.
Ko triclosan inoshandiswa sei mune zvimwe zvigadzirwa zvevatengi?
Iyo yakakura-spectrum antimicrobial chiitiko chetriclosan chatungamira mukubatanidzwa kwayo mune yakawedzera huwandu hwezvigadzirwa zvakagadzirirwa kushandiswa pamba senge sipo yemvura, masupa, mapuranga ekuchekera, vana matoyi evana, makapeti uye midziyo yekuchengetera chikafu.Rondedzero yakadzama yezvigadzirwa zvevatengi zvine triclosan inopiwa neUS Environmental Protection Agency (EPA) uye neUS NGOs "Environmental Working Group" uye "Beyond Pesticides" .
Nhamba inowedzera yezvinyorwa zvezvipfeko zvinorapwa nebiocides.Triclosan ndeimwe yevashandi vanopedzisa kugadzira micheka yakadaro .Micheka yakapedzwa netriclosan inobatwa ne-cross-linking agents kuti ipe yakasimba antibacterial properties.Pahwaro hweruzivo rwuripo, zvigadzirwa gumi nenomwe kubva kumusika wekutengesa weDanish zvakaongororwa kune zviri mukati memamwe akasarudzwa antibacterial makomisheni: triclosan, dichlorophen, Kathon 893, hexachlorophen, triclocarban uye Kathon CG.Zvishanu zvezvigadzirwa zvakawanikwa zvine 0.0007% - 0.0195% triclosan.
Aiello et al muongororo yekutanga yakarongeka yekuongorora kubatsirwa kwemasipo ane triclosan, akaongorora zvidzidzo zve 27 zvakadhindwa pakati pe1980 ne2006. Chimwe chezvinhu zvakakosha zvakawanikwa ndezvokuti sipo dzine zvishoma kudarika 1% triclosan dzakaratidza kusabatsirika kubva kune sipo isina antimicrobial.Zvidzidzo zvakashandisa sipo ine > 1% triclosan zvakaratidza kudzikiswa kukuru kwemazinga ebhakitiriya paruoko, kazhinji mushure mekushandisa kwakawanda.
Kushaikwa kuri pachena kwehukama pakati pekushandiswa kwesipo ine triclosan uye kudzikiswa kwechirwere chinotapukira kwakanetsa kuziva kana pasina kuzivikanwa kweiyo biological agents inokonzera zviratidzo zvehurwere.Ongororo mbiri dzichangoburwa dzemuUS dzakaratidza kuti kugeza maoko nesipo inorwisa utachiona hune triclosan (0.46%) kwakaderedza kutakurwa kwebhakitiriya uye kutamiswa kwebhakitiriya kubva mumaoko, zvichienzaniswa nekugeza maoko nesipo isina antimicrobial.
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Nguva yekutumira: Jun-10-2021