Yaimbozivikanwa se "goridhe rinochenesa", uye mukurumbira wayo uri mukuita kwayo kuchena kusingaenzaniswi kune rumwe rutivi, uye kuoma uye kushomeka kwekubviswa kwayo kune rumwe rutivi. Chirimwa cheGlycyrrhiza glabra ndicho chinobva Glabridin, asi Glabridin inongopa 0.1%-0.3% yehuwandu hwayo hwese, kureva kuti, 1000kg yeGlycyrrhiza glabra inogona kuwana 100g chete.Glabridin, 1g yeGlabridin yakaenzana ne1g yegoridhe chairo.
Hikarigandine inomiririra zvakajairika zvezvinoshandiswa mumiti, uye mhedzisiro yayo yekuchena inowanikwa neJapan
Glycyrrhiza glabra chirimwa cherudzi rweGlycyrrhiza. China ndiyo nyika ine zvirimwa zvakapfuma pasi rose, uye kune mhando dzinopfuura mazana mashanu dzemiti dzinoshandiswa mukurapa, pakati padzo dzinonyanya kushandiswa i licorice. Zvichienderana nehuwandu, mwero wekushandiswa kwe licorice unodarika 79%.
Nekuda kwenhoroondo refu yekushandiswa kwayo, pamwe chete nemukurumbira wayo mukuru, huwandu hwekutsvaga kukosha kwe licorice hauna kungopfuura nemiganhu yenyika chete, asiwo kushandiswa kwayo kwakawedzerwa. Sekureva kwekutsvaga, vatengi muAsia, kunyanya muJapan, vanoremekedza zvikuru zvizoro zvine mishonga inoshanda. Zvizoro zvemishonga 114 zvakanyorwa mu "Japan's General Cosmetics Raw Materials", uye kwatova nemarudzi mazana maviri ezvizoro zvine mishonga muJapan.
Inozivikanwa kuti ine simba guru rekuchenesesa, asi ndeapi matambudziko aripo pakushandisa kwayo?
Chikamu chinonyungudutsa che licorice chine mhando dzakasiyana dze flavonoids. Sezvo chiri chikamu chikuru chechikamu chayo chinonyungudutsa, halo-glycyrrhizidine ine simba rekudzivirira kugadzirwa kwe melanin uye ine simba rekudzivirira kuzvimba uye kuuraya oxidant.
Mamwe mashoko ekuyedza anoratidza kuti mhedzisiro yekucheneswa kwechiedza cheGlabridin yakakwira ka232 kupfuura iyo yevhitamini C yakajairika, yakakwira ka16 kupfuura iyo yehydroquinone, uye yakakwira ka1,164 kupfuura iyo yearbutin. Pakuti ungawana sei basa rakasimba rekucheneswa, chiedza cheGlabridin chinopa nzira nhatu dzakasiyana.
1. Kudziviswa kwebasa re tyrosinase
Nzira huru yekuchenesesaGlabridinndeyekudzivirira kugadzirwa kwemelanin nekudzivirira kukwikwidzana kwekuita kwetyrosinase, kubvisa chikamu chetyrosinase kubva mu catalytic ring yekuumbwa kwemelanin uye kudzivirira kubatana kwe substrate kune tyrosinase.
2. Mhedzisiro yeAntioxidant
Inogona kumisa kushanda kwe tyrosinase ne dopa pigment exchange pamwe nekushanda kwe dihydroxyindole carboxylic acid oxidase.
Zvakaratidzwa kuti kana paine huwandu hwe0.1mg/ml, photoglycyrrhizidine inogona kushanda pa cytochrome P450/NADOH oxidation system uye kubvisa 67% yemafree radicals, ayo ane simba guru rekuchengetedza maantioxidant.
3.Dzivirira zvinhu zvinokuvadza uye kurwisa UV
Parizvino, hapana tsvakurudzo yakawanda yakataurwa pamusoro pekushandiswa kwephotoglycyrrhizidine mukudzidza kweUV-induced skin photoaging. Muna 2021, munyaya iri mumagazini huru yeJournal of Microbiology and Biotechnology, photoglycyrrhizidine liposomes dzakadzidzwa nekuda kwekugona kwadzo kugadzirisa erythema yeUV inokonzerwa nechiedza uye chirwere cheganda nekudzivirira zvinhu zvinokuvadza. Photoglycyrrhizidine liposomes inogona kushandiswa kuvandudza bioavailability isina chepfu yakawanda pamwe nekudzivirira melanin zviri nani, zvichideredza zvinobudirira kuratidzwa kwekuzvimba kwecytokines, interleukin 6 uye interleukin 10. Nokudaro, inogona kushandiswa semushonga wekurapa wepamusoro kurwisa kukuvara kweganda kunokonzerwa nemwaranzi yeUV nekudzivirira kuzvimba, izvo zvinogona kupa mamwe mazano ekutsvagisa zvigadzirwa zvekudzivirira kuchena kwezuva.
Muchidimbu, simba rekuchena kwephotoglycyrrhizidine rinozivikanwa, asi hunhu hwaro hahunyungudike mumvura, saka rinoda zvakanyanya kugadzirwa uye kugadzirwa kwezvigadzirwa zvekuchengetedza ganda, uye parizvino mhinduro yakanaka kuburikidza netekinoroji ye liposome encapsulation. Uyezve, mufananidzoGlabridinMaposome anogona kudzivirira kupenya kwemifananidzo kunokonzerwa neUV, asi basa iri rinoda kuti kuyedzwa kwakawanda kwekiriniki kusimbiswe uye kuti mashandisirwo ekutsvagisa aitwe.
Zvigadzirwa zvekuchengetedza ganda zvine photoGlabridin muchimiro chekusanganisa zvinhu.
Kunyange pasina mubvunzo kuti photoGlabridine ine mhedzisiro yakanaka kwazvo yekucheneswa kweganda, mutengo wayo wezvinhu zvisina kugadzirwa wakanyanyawo kudhura nekuda kwekuoma kwekubvisa nekushandisa. Mukuongorora nekusimudzirwa kwezvekunaka, basa rekudzora mitengo rakabatana zvakananga nezviri mukati me tekinoroji uye maitiro esainzi. Nokudaro, inzira yakanaka yekudzora mutengo wemafomula uye kuwana mhando yakachengeteka uye inoshanda nekusarudza zvinhu zvinoshanda uye kuzvisanganisa mukubatanidza nephotoglycyrrhizidine. Pamusoro pezvo padanho rekuongorora nekusimudzirwa, kutsvaga kwakawanda kunodiwa maererano nekutsvagisa kwephotoglycyrrhizidine liposomes uye nzira dzekupedzisira dzekubvisa.
Nguva yekutumira: Nyamavhuvhu-30-2022